 |
|
|
Table 5. Summary of MRI Screening Studies in Women at Hereditary Risk for Breast Cancer
|
Series
|
Kriege [25]
|
Warner [28]
|
MARIBS [27]
|
Kuhl [33]
|
Totals
|
| N Patients |
Overall |
1,909 |
236 |
649 |
529 |
3,323 |
|
BRCA1/2 Carriers |
354 |
236 |
120 |
43 |
753 |
| N Screening Episodes |
4,169 |
457 |
1,881 |
1,542 |
8,049 |
| N Cancers |
Baseline |
22 |
13 |
20 |
14 |
69 |
| Subsequent |
23 |
9 |
15 |
29 |
76 |
| Annual Incidence |
9.5/1,000 |
|
19/1,000 |
25/1,000 |
|
| Detected at Planned Screening |
41 |
21 |
33 |
40a |
135 (93%) |
| N Detected by Each Modality |
Mammography |
18 |
8 |
14 |
14 |
54 (37%) |
| MRI |
32 |
17 |
27 |
39 |
115 (79%) |
| Ultrasoundb |
|
7 |
|
17 |
24 (37%) |
|
a2 additional cancers detected at planned 6-month interval ultrasound screening (not included in ultrasound detection proportion)
|
|
bRestricted to studies in which ultrasound was performed
|
References
-
Kriege M, Brekelmans CT, Boetes C, et al.: Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351 (5): 427-37, 2004.
[PUBMED Abstract]
-
Leach MO, Boggis CR, Dixon AK, et al.: Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS). Lancet 365 (9473): 1769-78, 2005 May 21-27.
[PUBMED Abstract]
-
Warner E, Plewes DB, Hill KA, et al.: Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination. JAMA 292 (11): 1317-25, 2004.
[PUBMED Abstract]
-
Kuhl CK, Schrading S, Leutner CC, et al.: Mammography, breast ultrasound, and magnetic resonance imaging for surveillance of women at high familial risk for breast cancer. J Clin Oncol 23 (33): 8469-76, 2005.
[PUBMED Abstract]
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