Adverse Effect	Reference
*The most severe adverse effects occurred in this study, which reported neurologic toxic effects such as excessive somnolence, somnolence plus confusion, and increased frequency of underlying focalmotorseizures; increased cerebral edema; and persistent confusion. In addition, the study reported myalgia, severe cutaneouserythema, pruritus, and anasarca of the extremities and face.
Anemia	[2,3]
Blood pressure elevation	[4,5]
Dizziness or vertigo	[6,7]
Excess abdominal gas	[4,8]
Fever and chills	[2,5-7,9-11]
General malaise with and without anorexia	[2,4]
Headaches	[1,4,6,7]
Hypocalcemia and hypercalcemia	[2,5]
Increased thickness of epidermis associated with skin peeling and faster-than-usual growth of nails	[11]
Maculopapular or itchy skin rash	[2,4,5,8]
Mild myelosuppression	[5,8,12]
Nausea and vomiting	[1,2,5-7]
Neurocortical toxicity, severe	[1]*
Numbness	[2]
Palpitations, tachycardia, or pressure in the chest with irregular heartbeat	[4,11,1,7]
Peripheral edema, facial edema, cerebral edema	[1,4]
Swelling, pain, or stiffness of small joints	[4,8,10,11]

References

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